which is the drug of choice for toxoplasmosis in pregnancy?

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Spiramycin, a macrolide antibiotic, is one of the drugs of choice for toxoplasmosis. It is approved for use during pregnancy in Europe, but in the United States it can be purchased only from the manufacturer. The adverse effects of spiramycin are usually mild and mainly produce gastrointestinal symptoms. Sulfonamides may also be used, but they have been associated with neonatal jaundice. Pyrimethamine is an antagonist of folic acid and is generally not recommended for use during pregnancy, but several reports have mentioned use of this agent among pregnant women.11

There are few data and no randomized clinical trials on the effectiveness of treatment in the presence of seroconversion during pregnancy. A European multicentre study suggested that treatment during pregnancy decreases the severity of congenital Toxoplasma in newborns but does not affect transmission rates.11,12

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which is the drug of choice for toxoplasmosis in pregnancy?

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