What triggers Hashimoto's Disease? Hypothyroidsm?

Question: I already know how the disease works, what makes it happen in people??

Answers:
Hashimoto's thyroiditisis the most common cause of hypothroidism in developed countries. It is an autoimmune disease. It is an autoimmune destruction of the gland. There is a female predominance (45-64 y/o). Disease is mediated by both cellular and humoral factors (T and B cells). B lymphocytes secrete autoantibodies against thyroglobulin and thryoid peroxidase (microsomes). Many patients have these antibodies, although the antibodies and not specfic for the disorder. Antibody is also secreted against TSH receptor (which is specific for Hashimoto and Grave's disease). In Hasimoto's , the antibodies to the receptor block the action of TSH (in Grave's the antibody has a stimluating effect cause hyperthyroidism). Laboratory diagnosis includes thyroid function tests and serum autoantibodies.

Other Answers:
Primary hypothyroidism is due to a decrease in TSH (thyroid stimulating hormone). A hormone produced by your Hypothalamus called TRH triggers your pituitary to release t3/t4 hormone, which triggers the cells of the thyroid to release TSH. Secondary hypothyroidism is due to a decrease in the production of TRH.

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