How do you die when you die from an overdose of toothpaste?
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Answers:
Sodium Fluroide poisioning.
Fluoride has several mechanisms of toxicity. Ingested fluoride initially acts locally on the intestinal mucosa. It can form hydrofluoric acid in the stomach, which leads to GI irritation or corrosive effects. Following ingestion, the GI tract is the earliest and most commonly affected organ system.
Once absorbed, fluoride binds calcium ions and may lead to hypocalcemia. Fluoride has direct cytotoxic effects and interferes with a number of enzyme systems; it disrupts oxidative phosphorylation, glycolysis, coagulation, and neurotransmission (by binding calcium). Fluoride inhibits Na+/K+ -ATPase, which may lead to hyperkalemia by extracellular release of potassium. Fluoride inhibits acetylcholinesterase, which may be partly responsible for hypersalivation, vomiting, and diarrhea (cholinergic signs). Seizures may result from both hypomagnesemia and hypocalcemia. Severe fluoride toxicity will result in multiorgan failure. Central vasomotor depression as well as direct cardiotoxicity also may occur. Death usually results from respiratory paralysis, dysrhythmia, or cardiac failure.
Sounds fun, right?
How in the wide wide world of sports can you od on _toothpaste_??!
Research:::
Fluorine content of toothpaste is about 1000ppm. Per a couple of different sites, it takes about 2 g of the toothpaste fluoride to become toxic so a person would have to swallow a minimum of 2 kilograms of toothpaste to become ill.
Good luck with that.
Well assuming that you can die from from an overdose of toothpaste then whatever active ingredient is in it would cause it to poison you. That's why you're not supposed to ingest it.
i have never heard of that before!
Umm, well, fluoride is the active ingredient in it, usually. And isn't fluoride the thing they use to clean out dead bodies with to prepare them for funerals? That's what I've heard before.
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