Would i know the difference if somebody changed my paxil anti deppressant with a placebo?


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You may you may not. It depends on the severity of your condition. A lot of the time however people are truly feeling the effects of knowing they are taking a medicine for something. It certainly can be a psychological thing. However, if you do have depression or anxiety you would probably notice if you were suddenly dealt placebos. It would depend mostly on how long you've been on the paxil. If you just started taking it you probably would never know. If you've been taking it steadily for quite some time, your friends and family might start making comments on your mood or actions, and you might then realize something was wrong. Great question though because there is a huge hype in the news about counterfeit prescription drugs being sold to the US right now. Lots of people are wondering if they've possibly been dealt a fake in the past after some counterfeits ended up in drugstores.
Yes you most definitely would. The SSRI's are what are called Systemic Medications. That is to say that your Serum (Blood) levels must Titrate to a Therapeutic or Effective level for the Medication to work for you. As opposed to other types of Centrally acting and other Psychotropic Medications. When the Blood level begins to drop you would definitely notice a change in how you were feeling both Physiologically and Emotionally. If it didn't then the Medication was serving no purpose. The question is...How much would you notice and that depends on many factors. Your Diagnosis, The Dosage and Schedule, Your Sensitivity and Responsivity to the Medication, How long you have been taking the Medication and other factors may play also...
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