If you've taken Zoloft and Wellbutrin, which did you prefer and why?

Question:

I have more anxiety than depression, I think, because I have lots of problems in social situations and a terrible time sleeping--can't turn off my brain. I'm also underweight. Going back to dr Monday, and she's going to prescribe something. I'd like your opinions on Zoloft and Wellbutrin, if you've taken both. Thanks

Answers:
I have taken both. They're actually two completely different types of anti-depressants.

Zoloft is an SSRI or seritonin re-uptake inhibitor. Most popular anti-depressants fall under this category. It basically causes higher levels of seritonin in your brain. This is linked with feelings of well-being and is important for sleep, among other things.

Wellbutrin works on dopamine and ephineprine. These are linked with focus and motivation. The main reason Wellbutrin can be good for anxiety and sleep is that it will tend to quiet your mind. So it's less of a direct effect for anxiety, but it can still be effective.

When I took Zoloft it was not for anxiety, and I only took it for about a month, but I didn't notice the kind of effect that I did with Celexa, which I took later specifically for anxiety. Within 3 days I felt a pretty dramatic change. I definately felt more confident. It had a big part in preventing panic attacks that I was having when speaking in groups. I know that Zoloft can have a lot of side effects though. The only one I noticed was sexual, which was significant but it didn't prevent anything from happening. I was also on a lower dose. Celexa, on the other hand, has very few. I'm on the maximum dose right now and for me, the side effects are nil. Then again, different people find that different brands work better for them. Paxil seems to be associated with social anxiety, but it's also associated with some nasty side effects.

Wellbutrin is great, but whether it will work for you depends on the source or the nature of your anxiety. The side effects aren't bad. I had some trouble sleeping in the beginning, but from what I understand I'm in the minority on that one.

Ask your physician about Paxil.

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If you've taken Zoloft and Wellbutrin, which did you prefer and why?

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