Antidepressant effect of Diphenhydramine?
Question:
Please give me web addresses that give information related to this
Answers:
In the 1960s it was found that diphenhydramine inhibits reuptake of the neurotransmitter serotonin. This discovery led to a search for viable antidepressants with similar structures and fewer side effects, culminating in the invention of fluoxetine (Prozac), a selective serotonin reuptake inhibitor (SSRI). A similar search had previously led to the synthesis of the first SSRI zimelidine from chlorpheniramine, also an antihistamine.
Diphenhydramine is an over-the-counter sleep aid that also has uses as an antihistamine, but I've never heard of it being touted as an antidepressant.
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