What are the negative effects of donating a kidney?

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Osteodystrophy, also know as bone disease, affects more than the bones in children with chronic kidney disease (CKD), it also impacts growth and cardiovascular development, according to new guidelines developed through the National Kidney Foundation’s (NKF) Kidney Disease Outcomes Quality Initiative (KDOQI) and published as a supplement to the October 2005 issue of the American Journal of Kidney Diseases. The guidelines, Bone Metabolism and Disease in Children with Chronic Kidney Disease, warn that osteodystrophy begins early in the course of CKD in children and that children must be in calcium balance in order to grow and develop properly.

“The guidelines recommend that practitioners place a greater emphasis on vitamin D nutrition in children with CKD, the levels of parathyroid hormone, and the excesses of calcium intake from the use of calcium-based phosphate binders in children with advanced CKD which can lead to the development of vascular calcifications,” said Craig B. Langman, M.D., co-chair of the NKF work group that developed the guideline.

Isidro B. Salusky, M.D., co-chair of the guideline work group, highlighted additional key findings:

In patients with CKD stages 2-4, calcium-based phosphate binders are effective in lowering serum phosphorus levels,
In patients with CKD stage 5 (dialysis), both calcium-based phosphate binders and the non-calcium, non-metal-containing phosphate binders are effective in lowering serum phosphorus levels, but the long-term use of calcium-based binders is associated with the development of vascular calcifications in such patients,
The most accurate diagnostic test for determining the type of bone disease associated with CKD is iliac crest bone biopsy with double tetracycline labeling and bone histomorphometric analysis,
In patients with CKD serum levels of phosphorus should be adjusted according to age appropriate levels. Therapy with active vitamin D sterols should be initiated early in the course of CKD to prevent bone deformities.
According to Dr. Langman, the guidelines also offer research recommendations for topics such as bone mineral density testing in children with CKD, the effects of growth hormone combined with potent vitamin D metabolite analogues, and optimal therapeutic strategies for osteodystrophy.

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Risks of infection, recovery period can take weeks and obviously pain because it is surgery.

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What are the negative effects of donating a kidney?

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