what is pathophysiology of pneumonitis?

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Pathophysiology: As a group, regardless of etiology, a common pathophysiology exists that begins with acute injury to the pulmonary parenchyma, leading to chronic interstitial inflammation, and ultimately progressing to the common end point of pulmonary fibrosis and tissue destruction.

The DPLDs typically manifest with the insidious onset of respiratory symptomatology, although onset can be acute and rapidly progressive, as in bronchiolitis obliterans-organizing pneumonia (BOOP) or acute interstitial pneumonitis.

Pathologically, all manifest histologically with disease in the interstitial compartment of the lung. The histologic patterns of usual interstitial pneumonitis (UIP), desquamative interstitial pneumonitis (DIP), nonspecific interstitial pneumonitis, hypersensitivity pneumonitis (HSP), lymphocytic interstitial pneumonitis, BOOP, giant cell pneumonitis, and granulomatous pneumonitis are most common and are centered in the alveolar, lobular, and lobar septa, impacting alveoli, small airways, and pulmonary vasculature.

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what is pathophysiology of pneumonitis?

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