how long does minocycline stay in your system?
Question:
Answers:
It takes 11-26 hours for the body to metabolize it and get rid of it.
Other Answers:
Minocycline is rapidly absorbed after oral administration and absorption is not significantly impaired by ingestion of food or milk. After single oral doses of 150 mg in humans, minocycline yields serum levels that are generally 2 to 4 times higher than those of most other tetracyclines at all time intervals. When serum activity is determined against a standard of tetracycline, 150 mg of minocycline gives activity levels 16 or more times higher than 250 mg of tetracycline at 24 to 48 hours, this difference being largely due to the much longer serum half life of minocycline.
Minocycline is widely distributed in body tissues, with higher concentrations being found in cerebrospinal fluid and sputum than with other tetracycline analogues. As in blood, the concentration in tissues is generally 2 to 4 times higher with minocycline than with tetracycline.
Following a single dose of two 100 mg minocycline HCL capsules administered to ten normal adult volunteers, serum levels ranged from 0.74 to 4.45 mg/mL in one hour and attained peak levels between 2 and 3 hours; after 12 hours, they ranged from 0.34 to 2.36 mg/mL. Therapeutic levels are 1-2 mg/mL. The serum half life following a 200 mg dose in 12 normal volunteers ranged from 11 to 17 hours, in 7 patients with hepatic dysfunction ranged from 11 to 16 hours and in 5 patients with renal dysfunction ranged from 18 to 69 hours. Between 55% and 76% of an administered dose is bound by serum proteins.
Minocycline is excreted via the faeces primarily and via the urine at a low rate. High serum protein binding and the lipophylic properties contribute to this low excretion rate. The urinary and faecal recovery of minocycline when administered to 12 normal volunteers is one half to one third that of tetracycline.
Source(s):
I am a pharmacist
http://www.greencrossremedies.com
More Questions and Answers
- oh no!not again!!?
- wen men call woman name wen ever they have sex . do they have deep feeling for them?
- What are the best shampoo for a very oily hair?
- If Hair is dead then why does it grow?
- serious question abt pcod?
- stop a runny nose?
- where can i find mouse-shaped kid's toothbrushes?
- Does my bum look big in this?