treatment of metastatic renal cell carcinoma with cns mets?


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First item is typically removal of the kidney (radical nephrectomy.) You usually see mets to the lung, lymph and bone before brain, but you said "cns" so I'm wondering if we're talking somewhere else in the spine or just brain.

Mets to the brain can usually be treated surgically as long as tumors are solid.

Radiation and immunotherapy are also usually protocol as well. Chemotherapy is used in some cases. The immunotherapy (alpha-interferon and interleukin) is more successful in cases with mets.

For information on how to live with cancer try site for American Cancer Society: http://www.cancer.org

Other Answers:
The bad part first: If it is metastatic then it is incurable.

There are well known cases of people with metastatic renal cell cancer who have lived for years. Thease are usually people who have low volume of disease. Also people who undergo kidney removal usually live longer.

If there are only 1or 2 lesions in the CNS then they may be surgically removed or treated with gamma knife. If more or big lesions then whole brain radiation will be required.

Recently there have been 2 drugs approved for renal cancer. These are not chemotherapy but targetted agents. One is sunitinib, other is sorafenib. They are multitargeted kinase inhibitors and work better than chemo or radiation. They usually work only in clear cell renal cancer though.
Hope this helps


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