Please please tell me everything you know about systemic mastocytosis.?
Question:
Answers:
Systemic mastocytosis is caused when mast cells collect in the tissues and can affect organs such as the liver , spleen , lymph nodes , and bone marrow.
Mastocytosis is a disease characterized by the presence of too many mast cells in various organs and tissues.
Description
The body has a variety of free-roaming cell populations that function as immunogenic agents. Most immunogenic cells fall into the category of white blood cells, but some remain in tissues and are not found in the blood. Mast cells are such a group.
The cause of mastocytosis is unknown. People with systemic mastocytosis have bone and joint pain. Peptic ulcers are frequent because of the increased stomach acid stimulated by histamine. Many patients with systemic mastocytosis also develop urticaria pigmentosa. These skin lesions itch when stroked and may become fluid-filled.
Systemic mastocytosis is only symptomatically treated. There is no known treatment that decreases the number of mast cells within tissue.
Other Answers:
Mastocytosis is a disorder in both children and adults. It is caused by the presence of too many mast cells in your body. You can find mast cells in skin, linings of the stomach and intestine, and connective tissue (such as cartilage or tendons). Mast cells play an important role in helping your immune system defend these tissues from disease. Mast cells attract other key players of the immune defense system to areas of your body where they are needed by releasing chemical "alarms" such as histamine and cytokines.
In cases in which mastocytosis is malignant, cancerous, or associated with a blood disorder, steroids and/or chemotherapy may be necessary.
Hope this helps
http://www.emedicine.com/med/topic1401.htm
http://www.medterms..com/scrip.
htt://www.aocd.org/skin/dermat.
I hope this helps.
I have S.M. It is a very complicated disease. I suggest you look it up online. Everybody who has it experiences different symptoms. I have stomach, joint, muscle, and bone problems. Some people with this disease will have to have chemotherapy. Sometimes the abnormal mast cells will come together and invade an organ, like cancer. Some people live a long life. This disease can be very painful. A lot of people have extreme allergies. I don't. I experience pain and stiffness. There are certain things that will trigger an attack, such as certain meds, sunlight, alchohol, dust, foods, heat, cold, and many other things. I find that summer here in Georgia kills me. I become sicker. It's hard to function. Cool weather is great!! Like I said before, this is the most complicated disease!! Most doctors can't tell you about it. I've went through life with people not believing me. Finally, I have diagnosis and people still don't understand. Thank you for wanting to learn about your friends diagnosis
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