Does any one know what is Periostin?
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Periostin is a disulfide linked 90 kDa, 811 amino acid protein originally isolated as a osteoblast-specific factor that unctions as a cell adhesion molecule for preosteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading. Additionally, periostin expression has previously been shown to be significantly increased by both transforming growth factor beta-1(TGFbeta1) and bone morphogenetic protein (BMP-2).
Click theses links for more info if you like:
http://www.biovendor.com/pdf/rd172045100...
http://www.google.com/search?sourceid=na...
a protein with structural and sequence homology with a TGF-ß-inducible gene, ßig-h3, is upregulated in colorectal cancers and their liver metastasis, and it may play a role in promoting growth in these tumors. In vitro studies reveal that periostin promotes growth and cell proliferation in colorectal cancers and that this effect can be abrogated with antibodies to periostin. Hope this helps. :-)
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