In the sickle cell anaemia phenomenon, what is AC, AS, SS, SC?.Thanks?
Question:
Answers:
Sickle cell anemia (a hemoglobinopathy-Anemias Caused by Hemolysis) is chronic hemolytic anemia occurring almost exclusively in blacks, caused by homozygous inheritance of Hb S. Sickle-shaped RBCs clog capillaries, causing organ ischemia. Acute pain (crises) may develop frequently. Infection, bone marrow aplasia, or lung involvement (acute chest syndrome) can develop acutely and be fatal. Normocytic hemolytic anemia is characteristic. Diagnosis requires Hb electrophoresis and demonstration of sickling in RBCs on an unstained drop of blood. Crises are treated with analgesics and other supportive measures. Transfusions are occasionally required. Vaccines against bacterial infections, prophylactic antibiotics, and aggressive treatment of infections prolong survival. Hydroxyurea decreases the frequency of crises.
AC / AS / SS / SC are different parental genetic combinations will effect the percentages of a child contracting sickle cell, or be a carrier of the trait.
The following organizations are good resources for information on sickle-cell anemia:
* American Sickle Cell Anemia Association
Please see the web pages for more details on Sickle cell anemia.
I think that you are referring to the hemoglobin electrophoresis blood test. This test identifies abnormal forms of hgb( hemoglobin- carries oxygen ). The more common types are A 1, A 2, F, S, & C. Hgb A 1, constitutes the major component of hgb in normal red blood cells ( RBC's). Hgb A2, is only a minor component of the normal hgb of the normal Hgb total. Hgb F is the major hgb component in a fetus but normally exists in only minimal quantities in a normal adult. Levels of Hgb F greater than 2% in patients' over 3 years old, are considered abnormal. Hgb F is able to transport 0 2 ( oxygen) when only small amts.of 0 2 are available ( as in fetal life) . Hgb S & F are abnormal forms of hgb that occur in American Blacks. SS probably means sickle shaped, SC probably means sickle cell. I hope that this helped !!
More Questions & Answers...