Anyone know what works better than salagen for radiation induced xerostomia?
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Data from human and animal models suggest that regular use of pilocarpine may not only improve patient quality of life but potentially prevent complications as well. Better methods of patient selection for therapy are needed since clinical response to pilocarpine cannot be predicted based on the duration of patient symptoms.
I am not aware of anything that works better than Salagen, but it is important to note that Salagen will only INCREASE salivary flow from existing salivary gland tissue. In other words, if the gland is destroyed by radiation, there will be no increase in salivation with Salagen, because there is no gland left to stimulate. It is better to start Salagen prior to radiation therapy in anticipation of decreased salivary output.
In the event that you can not increase salivary flow, consider using artificial oral lubricants, such as Biotene products. Be sure to add a daily topical fluoride to help prevent devastation through decay.
Check out http://www.laclede.com/ for more information on Biotene products.
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