Anyone know about squalene?

Question:

does it cause fine muscle tremors?

'am taking it to help cope up with depression. but the tremors are starting to get annoying.

Answers:
ACTIONS
Squalene has demonstrated proliferative activity in animal cancer studies; to date no human data are available. Squalene may have some radioprotective effects, but, again, there are no human data. Animal work suggests that squalene may also have a cholesterol-lowering effect, but this has not been tested in humans.

MECHANISM OF ACTION
Squalene is a key precursor in the biosynthesis of cholesterol. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase activity, thus reducing farnesyl pyrophosphate availability for prenylation of the ras oncogene, an activity that could account for its anti-proliferative effect in some animal cancer models. Apoptosis inhibition may also play a role in the anti-tumor effects of squalene in animals. The mechanism of the radioprotective effect of squalene is unknown.

PHARMACOKINETICS
Over 60% of ingested squalene is absorbed from the small intestine; from there it is carried in the lymph in the form of chylomicrons into the systemic circulation. In the blood, squalene is carried mainly in very-low-density lipoproteins and distributed to the various tissues of the body. A large percentage of squalene gets distributed to the skin. Squalene is metabolized to cholesterol.

INDICATIONS AND USAGE
Animal work suggests that indications could one day emerge for squalene in the prevention and treatment of some cancers, for immune enhancement and possibly for lowering cholesterol. It is not indicated for gastritis, joint pain and inflammation or to improve lung function.

RESEARCH SUMMARY
Squalene is being investigated as an adjunctive therapy in some cancers. In animal models, it has proved effective in inhibiting lung tumors. It has also demonstrated chemopreventive effects against colon cancer in animal models. Supplementation of squalene in mice has produced enhanced immune function and, in other animal studies, it has reduced cholesterol levels, prompting one researcher to suggest that it might be used to potentiate cholesterol-lowering drugs.

A mouse study showed squalene to confer radioprotection against lethal whole-body radiation.

CONTRAINDICATIONS, PRECAUTIONS, ADVERSE REACTIONS
CONTRAINDICATIONS
None known.

PRECAUTIONS
Squalene supplementation should be avoided in infants, children, pregnant women and nursing mothers.

ADVERSE REACTIONS
Those taking squalene supplements may have mild gastrointestinal symptoms such as diarrhea.

INTERACTIONS
None known.

OVERDOSAGE
There have been no reports of overdosage.

DOSAGE AND ADMINISTRATION
Squalene is a liquid that is available in capsules for oral use. Doses of 500 milligrams to 4 grams are used; the higher doses are used by some cancer sufferers. The source of squalene is usually from shark liver oil and sometimes from olive oil.

Squalene should not be confused with squalamine, which is an unusual steroid found in the dogfish shark and which has antibiotic properties.

HOW SUPPLIED
Capsules — 450 mg, 500 mg, 1000 mg

LITERATURE
Kelly GS. Squalene and its potential clinical uses. Altern Med Rev. 1999; 4:29-36.

Newmark HL, Squalene, olive oil, and cancer risk: a review and hypothesis. Cancer Epidemiol Biomarkers Prev. 1997; 6:1101-1103.

Rao CV, Newmark HL, Reddy BS. Chemopreventive effect of squalene on colon cancer. Carcinogenesis. 1998; 19:287-290.

Smith TJ, Yank GY, Seril DN, et al. Inhibition of 4-(methylnitrosamino)-1-(3-pyr... lung tumorogenesis by dietary olive oil and squalene. Carcinogenesis. 1998; 19:703-706.

Storm HM, Oh SY, Kimler BF, Norton S. Radioprotection of mice by dietary squalene. Lipids. 1993; 28:555-559.

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Anyone know about squalene?

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