What is the correct/best dosage of SAMe for depression?
Question:
Answers:
For depression, arthritis, fibromylagia, and liver disorders:
Take 400 mg of SAMe twice a day.
If symptoms fail to improve after three weeks, try increasing your dose to 400 mg three times a day. On the other hand, if symptoms lessen with 400 mg twice a day, you can try to lower the dose to 200 mg twice a day.
To avoid a toxic buildup of Homocysteine molecules (which are formed when SAMe breaks down) be sure to take a high-quality Vitamin B complex supplement along with SAMe. These vitamins help metabolize homocysteine, which in high concentrations poses the risk for various health problems including heart attack and stroke.
A standard recommendation is to take 100 mg of a B complex once a day, regardless of the SAMe dose.
If you're particularly sensitive to medications, start out with half the recommended daily dosage and work up to the full amount after a week.
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